More is exponentially less: marginal utility in critical care research

BACKGROUND: Randomized clinical trials (RCT) in critical care mostly return negative results. The research community discusses strategies to improve RCTs design. METHODS: This paper presents a theoretical framework based on marginal utility treat the problems of hypothesis generation and treatment effects valuation recently published high-quality studies as instances where such predicts irrelevant findings. RESULTS: Blindness utility, i.e., inobservance proposed intervention, is common RCTs. CONCLUSION: Critical are usually blind are, therefore, prone produce